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They also have specific contraindications, so its important to discuss your full medical history with your clinician

[1] [6] Whilst these reductions are modest, they are clinically meaningful when considered alongside the medication's other cardiovascular benefits

In phase 2 clinical trials published in the New England Journal of Medicine in 2023, participants on the highest dose of retatrutide lost an average of 24.2% of their body weight over 48 weeks

It contributes to early satiety and weight loss, but also underlies many of the adverse effects and emergency department presentations associated with these medications

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Al-kuraishy et al