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This absence of foundational pharmacokinetic information constitutes a major knowledge gap with direct implications for clinical application, dosing strategies, and safety monitoring

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The specific protocol is designed by the prescribing physician based on the patient's indication, injury severity, and health profile

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Thermal shift assay (TSA) Samples were prepared by using a final concentration of 0.25 mg/ml TGR diluted in TGR reaction buffer to the desired volume