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Two separate human clinical trials (ulcerative colitis and multiple sclerosis) proceeded without significant adverse event reporting

Three consecutive prolines at positions 35 (Pro-Pro-Pro) and an additional proline at position 8 create local conformational rigidity through the unique angle constraints of pyrrolidine-containing residues

Maintaining an optimal concentration helps preserve stability and bioactivity

No mixing, vial reconstitution, or spray-bottle transfer is required

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