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On the surface of the cartilage, there is a layer of special phospholipids
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This decrease in energy expenditure means less heat generation at the cellular level, which your nervous system may interpret as a drop in core temperature
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These processes are associated with a significant increase in the activity of key antioxidant enzymes such as SOD and glutathione peroxidase (GSH-PX), as well as a marked reduction in the oxidative stress marker MDA
For instance, a retrospective observational study on hospitalized elderly patients with type 2 diabetes found that patients treated with GLP-1 receptor agonists combined with basal insulin had an increase in limb skeletal muscle mass, while those treated only with basal insulin showed a slight decrease, suggesting that under specific clinical management conditions, GLP-1 receptor agonists may help maintain muscle mass [61]
