Journal of Medicinal Chemistry (2017) Kraus D, et al
Central administration into brain ventricles produces more pronounced effects on food intake and body weight than peripheral administration, confirming the importance of hypothalamic MC4R activation

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Allow us to take you back to middle school science class for a minute
Receptor binding studies Cell Culture and transient transfection HEK-293 cells lacking the calcitonin receptor (CTR-HEK 293 cells) were given by Drs