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Drinking sufficient water, increasing dietary fibre, and maintaining regular physical activity may help improve symptoms

Patients with active suicidal ideation, recent psychiatric hospitalization, or unstable bipolar disorder should not start a GLP-1 agent through any telehealth platform without documented coordination with their treating psychiatrist

PMC (PMC12469573)

This is the structural reason the reward indication may be more workable than the neurodegeneration indication

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Tirzepatide independently causes a modest heart rate increase, averaging 2-4 beats per minute in the SURMOUNT clinical trials